Italy produced one of the biggest upsets in recent Six Nations Championship history, beating England 23-18 in Rome for their first ever win over England after 32 failed attempts.
England looked in control at 18-10 with just over 20 minutes left after tries from Tommy Freeman and Tom Roebuck, but yellow cards to Sam Underhill and captain Maro Itoje turned the match completely.
Italy seized the momentum, with Paolo Garbisi helping orchestrate the comeback before Leonardo Marin crossed for the decisive late try after a slick attacking move also involving Tommaso Menoncello and Monty Ioane.
The final whistle sparked wild celebrations around the stadium, while England were left stunned after a defeat that piles more pressure on Steve Borthwick ahead of a difficult finish to the tournament.